Neuromuscular blocking agents for acute respiratory distress syndrome: how did we get conflicting results?
نویسندگان
چکیده
منابع مشابه
LETTER TO THE EDITOR Potential Hazards of Neuromuscular Blocking Agents in the Treatment of Acute Respiratory Distress Syndrome. Comment on: “Neuromuscular Blockers in Early Acute Respiratory Distress Syndrome”
While the mechanisms responsible for the adjusted mortality benefit reported by Papazian et al. remain speculative, it is highly likely that lower transpulmonary pressures (TPPs) in the cisatracurium group were responsible for some portion of the reported benefit. This is suggested by the three-fold incidence of pneumothorax in the placebo group compared to the cisatracurium group despite no di...
متن کاملBenefits of Neuromuscular Blocking Agents in Acute Respiratory Distress Syndrome Patients: What Is the Evidence?
NMBAs are commonly used in ARDS (25–55% of patients), but the benefits and the risks of using these agents are controversial. Recent data suggest that a continuous infusion of cisatracurium during the first 48 h of ARDS, particularly for patients with a PaO2/FiO2 ratio less than 120, can decrease 90-day inhospital mortality. NMBAs do not appear to be an independent risk factor for ICU-acquired ...
متن کاملHow Did We Get Here?
W hen we talk among ourselves about our business, we use lots of abbreviations and acronyms. We take a lot of things for granted. To understand what I’m talking about all you need to do is try to explain how you get paid to somebody. AWP, WAC, discount, PBM, RA, EOB, DIR, copay, insured amount, rebate, clawback, etc. This is the barrier we face when talking to legislators. We are in a complicat...
متن کاملHow did we get here?
I t is rare that science owes a debt to law. To lawmakers, surely, such as those who regularly make generous appropriations to the National Science Foundation and the National Institutes of Health. But law, in the sense of the process and products of litigation? It’s hard to imagine. But this special supplement is deeply in debt to law in just that sense. The funding that supports the research ...
متن کاملNeuromuscular blocking agents in acute respiratory distress syndrome: a systematic review and meta-analysis of randomized controlled trials
INTRODUCTION Randomized trials investigating neuromuscular blocking agents in adult acute respiratory distress syndrome (ARDS) have been inconclusive about effects on mortality, which is very high in this population. Uncertainty also exists about the associated risk of ICU-acquired weakness. METHODS We conducted a systematic review and meta-analysis. We searched the Cochrane (Central) databas...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Critical Care
سال: 2019
ISSN: 1364-8535
DOI: 10.1186/s13054-019-2586-3